Do patients who underwent leukapheresis before receiving a COVID vaccine need a COVID booster after they are re-infused with modified CD4 cells that have not been exposed to the vaccine?

The COVID vaccine activates a large number of cells throughout the body, and many will be within tissues. The leukapheresis collected only a fraction of total lymphocytes, so most were left behind including COVID-immune cells. Plus, all of the CD4 T cells are returned to you during the cell infusion with the HIV-specific CD4 T cells now greatly increased in number. These statements apply to all COVID vaccines.