Don’t you have to remove HIV from the transplanted cells as well as add protection to the exterior wall of the cells?
The AGT103-T vector greatly lowers the cell surface levels of CCR5 but does not impact CXCR4 for safety reasons. The HIV DNA remains in the cell but expression of HIV proteins is severely reduced by destabilizing the virus RNA. This is a special feature of AGT103-T: the modification protects against virus entering a cell and also prevents an already infected cell from releasing virus ever again.